First you'll need to fix the source of the problem and make sure the spam doesn't restart. Make sure your server updates are done, and probably more importantly make sure any 3rd party applications such as Wordpress and it's plugins, drupal, phpmyadmin, etc are all updated. Check your apache logs for lots of POST lines, sometimes that will help you find the problem. Then wait until Monday for the spam reports to stop, they'll keep coming in over the weekend as people check their email and report the spams that had been sent. Then after the spam reports stop it should be safe to request delisting from blacklists as needed. It's best if you can be sure you found the source of the problem and have fixed it before submitting the delisting requests.