I'm still using Trillian. (old habits and all). I run the pro version and currently have it connecting:
2 YIMs
1 Jabber (google)
2 XMPP (custom / homegrown corporate work) (one I'm building one we're currently paying a 3rd party to host)
1 ICQ
1 AIM
1 windows live / MSN
1 skype
1 facebook...