Is your email being rejected by large email service providers?
First, if you are sending through your ISP SMTP relays please contact your ISP. The trouble with ISP SMTP relays is that they are usually shared by all of their customers. If any one of their customers sends spam, then all of their customers, including you, will get blocked. The only way around this problem is to get a quality 3rd party email service, such as LuxSci SMTP, and use their SMTP relays for sending your email.
If you are running your own mail server there are several things you can check:
What is your Sender Score? Large email providers block IP addresses with low sender scores.
Does your mail server have a static name such as mail.example.com, with a PTR record in reverse DNS, and a matching A record, all with TTL's of 86400 or greater?