Hello,
Sending to quality email lists and sending from quality newsletter services will help.
Using a newsletter service is generally going to be better than both an application on your computer and/or using a dedicated SMTP service.
Some email newsletter services to try are
Constant Contact,
MailChimp, and
AWeber.
The reputation of an IP address matters more than the geographic location of an IP address.
Sending targeted emails only to email address that want your email, and interact with it, is most important.
By interacting I mean your recipients are opening the email, clicking a link within the email, etc.
The big services monitor activity and recipients that delete the email without interacting can have a negative impact on your deliverability.