I used Ghostery when I was using Chrome (Comodo Dragon) and Opera, since neither of them has NoScript. I still have Opera installed (with Ghostery) but only use it as a back-up for emergencies. Can't even remember the last time I used it.
I'm much more of a FF user and simply use NoScript and ABP on it. I never felt the need to have Ghostery on FF, as I don't know what, if any, added security would be provided by it.
But I can say that when I was using CD and Opera more frequently, Ghostery never gave me any trouble.